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Studies that have monitored blood levels of ROS during pregnancies with FGR have shown an increased level of MDAa breakdown product of lipid peroxidation [49], as well as reduced plasma TAC [50] both in maternal plasma, placental tissue [51], and cord blood in the infants [52]

Additionally, the use of immunofluorescence assays to detect H2AX foci offers a powerful approach for identifying double-strand breaks in DNA, a direct consequence of ROS-mediated damage

Cheng I, Yang J, Tseng C, Wu J, Shariff-Marco S, Park SL, Conroy SM, Inamdar PP, Fruin S, Larson T, et al

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