Duncan explains
By activating two hormone receptors GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) this regulates blood sugar, reduces appetite, and improves how the body processes nutrients
Patients with PWS are characterized by neonatal hypotonia, hyperphagia, developmental and cognitive delay, behavioral problems, dysmorphic features, and failure to thrive [3]
Inadequate caloric intake, increased physical activity, or alcohol consumption can precipitate hypoglycemia in any patient with diabetes, but these factors become more relevant when tirzepatide is combined with other glucose-lowering agents
[1] [4] For patients requiring long-term PPI therapy (beyond 8 weeks) to control reflux symptoms whilst on tirzepatide, review by a gastroenterologist may be appropriate to investigate underlying causes and consider endoscopic evaluation, as recommended in NICE CG184