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More than 75% of patients experience at least one side effect, with nausea, constipation, diarrhea, and vomiting being the most frequently reported ^2

Thus, resistance to anti-VEGF drugs in advanced-stage breast cancer may be explained by the dominance of FGF-2 and other pro-angiogenic factors in such stage of the disease (Schneider and Miller, 2005)

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Regulation of Insulin and Glucagon Secretion in Pancreatic Islets The pancreas expresses ghrelin, GOAT and GHSR, serving as a site for both local production and action of the ghrelin system [179,180,181]

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