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Recent findings from the KEEPS trial indicate that oral CEE may slow the accumulation of epicardial fat tissue and impede the progression of coronary atherosclerosis (172)

To assess whether RT probe binds to any proteins or reacts with free cysteine residues in some proteins that may interfere with the final ratio readouts, we incubated RT with cell lysate, which was dialyzed using a 3 K cut-off membrane to remove all small molecules including GSH, and observed no significant changes in fluorescent signal ratios even at the highest lysate concentration shown (protein concentration is 36 mg ml 1 based on a BCA assay), suggesting that there is no non-specific interactions or reactions between cellular proteins and RT which could significantly change the ratio readouts (Fig

In other words, the preservative is the reason the product sits in a different handling class from preservative-free sterile water

The frequency of monitoring is determined by the prescribing physician based on the protocol and individual response