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Human Study Sublingual Glutathione Shows Enhanced Delivery of Active Glutathione While intravenous administration of reduced glutathione has been shown to significantly impact this ratio (GSH:GSSG), oral supplementation has been ineffective because the reduced glutathione is either a) broken down to simple amino acids during digestion or b) are oxidized and no longer active when absorbed, or a combination of a and b

13, 14 However, serious problems are rare