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The Problem of Caloric Restriction Severe caloric deficit, whether from medication-induced appetite suppression or intentional restriction, triggers adaptive responses that consume muscle tissue

Palpitations often come from triggers like caffeine, stress, or intense exercise

Pregnancy or planning pregnancy , as GLP-1 receptor agonists are not recommended during pregnancy

In Canada, synthetic injectable peptides are generally regulated as prescription drugs under the Food and Drugs Act, and Health Canada has issued public advisories (April 2026 and earlier) cautioning that unauthorized injectable peptide products are illegal regardless of whether they are labelled 'for research use only.' Research-grade AOD-9604 supplied by Koipeptides is intended for in vitro laboratory study only and is not authorized for any human or veterinary application