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We hypothesize that neutral lipids bearing ESA-derived acyl chains undergo spontaneous or enzyme-mediated oxidation after achieving a critical concentration in lipid droplets

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The study addressed two questions: whether the fragment retained activity when delivered enterally rather than parenterally, and whether the effects observed in rodent models translated to human adipose tissue at the cellular level

The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

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