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Prophylactic lateral ND for MTC without evidence of neck metastasis and distant metastasis could not achieve a consensus agreement in the ATA guidelines committee, but they recommend neither for nor against prophylactic lateral ND being considered based on serum calcitonin levels [1]

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Open questions in the GHK-Cu field include the specific cellular targets responsible for the broad transcriptomic effects, the relationship between the copper-delivery role and the direct peptide-only effects (if any), the comparative biology of GHK-Cu and related copper-peptides in defined cellular contexts, and the translation of cell-culture and animal-model findings to clinical-research endpoints under controlled study conditions

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