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GLP-1 medications require ongoing use to prevent regaining up to two-thirds of the lost weight

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Early PD is associated with lower substantia nigra synaptic integrity, while cortical, caudate and brain stem synaptic loss was observed in more advanced PD and in PD patients with dementia [253,254,255]

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GIP enhances glucose-dependent insulin release, while GLP-1 delays gastric emptying, suppresses glucagon, and promotes satiety