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Fishman EK, Soyer P, Bliss DF, Bluemke DA, Devine N

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The needle should be inserted at a 90-degree angle for most patients, though very thin individuals may need to use a 45-degree angle or pinch the skin to ensure subcutaneous rather than intramuscular injection

Van wijngaarden JP, Doets EL, Szczeciska A, et al

437440 This regulatory mechanism thus integrates repression of uptake transporters and up-regulation of efflux transporters over a very large range of metal activity using a single regulator, allowing for a coordinated cellular response to extreme metal toxicity