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doi: 10.1016/j.clim.2017.07.001 32 KorenO.GoodrichJ

The link between GSTP and cancer is most obvious in the overexpression of GSTP in many cancers, but it is also supported by the fact that the transformed phenotype of tumor cells is associated with aberrantly regulated kinase signaling pathways and cellular addiction to overexpressed proteins

Immune & Inflammation-Related Research Glutathione is also commonly researched in laboratory and experimental models involving: Immune-related signaling pathways Cellular stress-response mechanisms Inflammation-related signaling investigations Cellular-resilience and physiological-maintenance pathways Research involving these pathways continues to evolve within broader antioxidant-support and physiological-resilience research models

Glutathione plays a central role as an antioxidant against ROS, thus regulating the signaling pathways involving cellular homeostasis