Possible interference with thyroid hormone levels, which may impact metabolism
, originally developed at the University of Arizona, is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (-MSH) that has been shown to induce skin pigmentation through melanogenesis and thereby subsequently reduce sun (UV) damage to UV exposed skin in preliminary studies and clinical trials
Gastrointestinal adverse reactions, including diarrhea, were the most common reason for treatment discontinuation in clinical trials, with approximately 4-7% of patients discontinuing due to GI events
Systemic vascular stiffening in HFpEF described above is associated with exercise-induced pulmonary hypertension that is partially reversible with the administration of NO therapies [79]
Use for weight loss medication in non-diabetic patients should be considered with caution and under medical supervision, as there are factors unique to each individual that must be considered
