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Mesenchymal stem cells (MSCs): For immunomodulation and trophic support ( Preclinical models and early-phase trials have shown motor improvement and graft survival, but issues such as immune rejection, tumorigenicity, and ethical concerns need resolution ( 5.6 CRISPR-Cas9 and genomic correction CRISPR-Cas9 enables precise genome editing and holds transformative potential for monogenic PD, particularly: Correction of LRRK2 G2019S , SNCA triplications, or PINK1 mutations

This protective effect was further validated during parthenogenetic activation, where aged oocytes displayed a fragmentation rate reduction of approximately 27% following Epitalon treatment