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While the magnitude was generally modest (single-digit beats per minute in most cases), this cardiac signal is one of the primary reasons retatrutide remains investigational and is undergoing extensive Phase 3 safety monitoring

SARS-CoV-2 inflicts severe respiratory symptoms with a substantial pulmonary dysfunction, which may include severe arterial hypoxemia (low blood oxygenation) resulting in acute respiratory distress syndrome (ARDS) 118

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It also has been described that -glutamylcysteine, the intermediate of GSH biosynthesis, is able to act as a Gpx1 cofactor in mitochondrial H 2 O 2 detoxification, mimicking the physiological properties of GSH (Quintana-Cabrera et al., 2012)