In conclusion, using a low-carnitine tilapia model, the present study has shown that dietary l-carnitine can be physiologically utilised in fish, and it has the effect of reducing lipid accumulation in the liver
Intracellular unesterified fatty acids must first undergo thio-esterification to coenzyme A, a process catalysed by acyl-CoA synthases and consuming the equivalent of two ATP, with formation of acyl-CoAs, i.e., to activate fatty acids
Similarly, long-term treatment with the carnitine inhibitor meldonium can induce adaptive cardioprotective effects by altering energy metabolic pathways [299]
86,129 During T cell activation, ZIP8 facilitates zinc transport from the lysosome to the cytoplasm, resulting in increased production of IFN-
Lipid peroxides damage cell membranes, disrupting the intestinal epithelial barrier and increasing permeability, allowing harmful substances and bacteria to enter underlying tissue and triggering an immune response (38)