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[6] Oral Dosing Guide Larazotide is an oral, luminally-acting peptide, so its dosing is a record of what appeared in the trials rather than a titration schedule and its most striking feature is an inverted dose-response, where the lowest maintenance dose is the one that worked

Its anti-inflammatory properties are much weaker than those of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, which inhibit both COX-1 and COX-2 and can irritate the stomach and gastrointestinal (GI) tract

[129] Shoba G, Joy D, Joseph T, et al

Vitamin D Receptor Negatively Regulates Bacterial-Stimulated NF-kappaB Activity in Intestine