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Clinical studies show semaglutide produces 15 to 20 percent average weight loss compared to 20 to 25 percent for tirzepatide

So you can see that in the middle there with the little green mark there around insulin glargine (Lantus) which put on a bit of weight

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Tesofensine may produce a modest increase in resting energy expenditure through its effects on norepinephrine and central nervous system stimulation