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The demonstration was made that the alterations in the expression of iron maintenance proteins in PR cells were impeded by MLT, which suppressed the GSK-3 signaling pathway and hindered Fyn-dependent Nrf2 nuclear translocation (150)

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Thats why therapies like CJC-1295 focus on restoring the natural signals rather than replacing the hormone outright

PMID 17582757

However, the "safety" of a supplement also depends on its purity and how well your body can actually use it