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As an anticancer treatment targeting mitochondrial metabolism, ES not only increases oxidative stress and ROS formation, but also triggers a novel cell death pathway through the accumulation of copper ions, according to recent findings (173)

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doi: 10.1016/j.cdtm.2020.11.002 192 FenouilletEVigourouxASteinbergJGChagvardieffARetornazFGuieuRet al

Free radicals can have several centers, such as oxygen, nitrogen, sulfur and carbon

The acquisition parameters were as follows: echo time (TE) of 3.4 ms, repetition time (TR) of 7.4 ms, flip angle of 8, field of view (FOV) of 220 220 mm, slice thickness of 1 mm, and 180 contiguous sagittal slices