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A follow up study using radio-ligand PET technology to measure receptor occupancy demonstrated a high degree of GLP-1R occupancy but no detectable GCGR occupancy suggesting that in vivo SAR425899 may be acting in effect as a GLP-1 analogue and not a co-agonist (87)

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Acknowledgements Thanks to the Taikang Health Investment Youth Medical Research Start-up Fund (2022018) for supporting this research