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Perhaps our observed microglial viability elevations with multi-agonists, relative to exendin-4, could be attributed to combined GLP-1R and GIPR signaling along neurotrophic pathways mediated by MAPK/ERK and mTOR (Figure 6), although synergistic trophic effects of joint GLP-1R/GIPR stimulation in microglia have not yet been observed [76], highlighting an avenue for further research

Cureus 15 , e47559 (2023)

With a simple, once-weekly GLP-1 treatment designed just for you, you could lose up to 20% of your body weight

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