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As discussed above, unlike Y37 rAmy , P37 Cagri does not interact directly with RAMP1 or RAMP3, which likely decreases the stability of the ECD interface, leading to increased dynamics relative to the rAmy-bound AMY 1 R and rAmy-bound AMY 3 R (Fig

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Clinical trials did not include pregnant or breastfeeding women, children, elderly individuals over 65, or those with active malignancy or severe organ dysfunction

Most had a calcium score at or near zero, with an average LDL of 112