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Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J Med Chem , 2017;60(12):5015-5028

One alternative pharmacotherapy has been to administer inosine, a purine that is converted in the body to UA

Plausible mechanisms include weight lossmediated benefit, metabolic regulation and direct antiinflammatory effects, but current data are limited by small samples and uncontrolled designs

Sasaki I, Bijani C, Ladeira S, Bourdon V, Faller P, Hureau C (2012) Interference of a new cyclometallated Pt compound with Cu binding to amyloid- peptide