While GLP-1 medications are meant for long-term use, this is not always feasible for every patient
Another open question concerns the role of membrane contacts in mTORC1 phosphorylation of TFEB and other noncanonical substrates, which requires RAGRagulator but not RHEB 6,20,42
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While direct evidence in the context of GLP-1RA remains limited, these approaches may enable identification of early molecular signatures of treatment response and stratify patients based on underlying plaque biology
Common side effects include nausea, vomiting, diarrhoea, constipation, decreased appetite, and fatigue
