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Like all drugs in this class, they carry a boxed warning on the US label that they should not be used in persons with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 because of a signal in rodents that these medications have a dose- and duration-dependent risk of thyroid C-cell tumors [18, 19]
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Although quite similar, AhR typically binds dioxin-like compounds and SXR typically binds non-dioxin like compounds (Van den Berg et al., 2006)
Lancet 2005;366(9496):15581560
Mild Tachycardia In some cases, semaglutide may cause a slight increase in heart rate, a condition known as tachycardia
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