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In antiquity, the disorder was often conflated with leprosy, an infectious disease

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Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Under the iron-rich, ROS-prone conditions characteristic of lesions, this perturbation engages a coordinated program of RCD across intersecting pathwaysnot only ferroptosis but also necroptotic and pyroptotic signalingwhile ferritin handling and mitophagy status further skew redox homeostasis toward irreversible injury in EESCs