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Participants were prescribed either semaglutide (oral or subcutaneous) or tirzepatide (subcutaneous) between 2018 and 2024
Transcriptional analysis of colonic epithelial cells: The study performs transcriptional analyses of isolated intestinal epithelial cells from inflamed IL-10-/- mice to identify changes in epithelial differentiation and metabolic profiles using qRT-PCR and assessing mRNA expression of genes involved in epithelial differentiation and various metabolic pathways (mitochondrial metabolism, glycolysis, autophagy)
Paradoxically, rapidly improving blood sugar can worsen diabetic retinopathy in susceptible individuals, especially those with longstanding, poorly controlled diabetes and high baseline A1c
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Overweight and obesity are recognised as chronic conditions
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