The black box warning notes that GLP-1s such as Mounjaro are contraindicated for individuals with a history or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
Oral obesity pipeline targets focusing on GLP-1/GIP dual agonists (Ecnoglutide, CT-388, DAPIGLP-1 ), amylin analogs (Pramlintide, Cagrilintide, Petrelintide) and CB1 inverse agonists (Inv-101, JD-5037, MRI-1867) provide alternative mechanisms and possible complementary actions
GLP-1 therapy changes some of them
Companies like Percusense have multi-analyte sensors (like a CGM) that can measure lactate, glucose, ketones, oxygen, and more
The comparison between oral and injectable tirzepatide shows that injectable delivery remains the gold standard for maximum weight loss efficacy