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When designing dose-escalation studies, establish three or four dosing tiers to identify threshold and saturation effects

Secondly, we combined data from trials that varied in duration, baseline characteristics, and types of AOMs, which might result in heterogeneity to the meta-analysis, so we used a random-effects model for statistical analysis

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hypothesize that the brain exposure levels were insufficient to activate the central MC system for weight loss

NEDSST is characterized by developmental delay, often with motor and speech delay, mildly impaired intellectual development (in most patients), learning difficulties, and behavioral abnormalities, including ASD (Stolerman et al., 2019