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As a result, new indications for weight management have emerged: for example, liraglutide (Saxenda) and semaglutide (Wegovy) are FDA-approved for chronic weight control, often at higher doses

These results suggest that GLP-1RAs inhibit bile acid synthesis through SREBP-2 suppression in PA-treated cells, possibly linked to reduced hepatic cholesterol levels following GLP-1RA treatment

To get there, we need to systematically study smaller doses of real GLP-1 therapies in people with different conditions