TGF- plays a key role in renal fibrosis, leading to tubulointerstitial fibrosis and glomerulosclerosis by promoting the production of inflammatory factors and fibroblast proliferation
Lanni, G
Thus, preventing the interaction between FcRn and IgG was found to be attainable by the use of peptides, active competition by large amounts of IgG, mAbs, and fusion proteins containing Fabs specific for FcRn, Fc-engineered IgGs, and affibodies
Compared with WT littermate F10 f/f mice, male and female F10 f/f Villin Cre mice showed unaltered postprandial GIP and GLP-1 levels (Figure 1, N and O), as well as IEC transcript levels of Gip and Glp1 and the upstream transcription factors Rfx6 and Pdx1 (Supplemental Figure 3G)
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