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When weight loss is desiredwhether for metabolic health in diabetes or general weight managementa modest caloric deficit of approximately 600 calories daily typically produces gradual, sustainable weight loss of around 0.5 kg per week

Reward, dopamine and why food feels different Hardaway says many patients report that foods they once craved no longer hold the same appeal while taking GLP-1 drugs

Almey A, Arena L, Oliel J, Shams WM, Hafez N, Mancinelli C, et al

The immune system may recognize the medication as a foreign substance, leading to the release of chemicals called cytokines

This reflects central appetite circuit modulation in the brain