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Once-weekly administration: The long-acting formulation supports convenient dosing schedules in clinical protocols

As a rough guideline, many providers use a ratio where the daily sublingual dose divided by 7 (to account for daily vs weekly dosing) and then multiplied by a bioavailability correction factor gives the approximate weekly injection dose

The landmark cardiovascular outcome trial, SUSTAIN-6, reported that semaglutide led to a marked reduction in major adverse cardiovascular events, such as non-fatal stroke and non-fatal myocardial infarction, among individuals with type 2 diabetes at high cardiovascular risk

Because they act through non-overlapping mechanisms, some protocols examine them in combination or parallel though combination research should have a clear mechanistic rationale

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