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In obese mouse models, liraglutide improved insulin sensitivity in visceral adipose tissue, which was associated with reduced endoplasmic reticulum stress and increased Akt phosphorylation following insulin stimulation ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

Neurochemical biomarkers Acetylcholinesterase (AchE) activity was assessed by using commercial rat ELISA kits obtained from Elabscience (cat no

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The effect of free fatty acids on growth hormone (GH)-releasing hormone-mediated GH secretion in man