Key Takeaways Weight loss shots with B12 is a broad term covering pure B12 injections, MIC shots, Lipo-C shots, and other compounded formulas each with different evidence bases Pure B12 injections do not cause weight loss in people with normal B12 levels the clinical benefit in deficient patients is real but indirect MIC shots and lipotropic injections have weak clinical evidence the Obesity Medicine Association does not list them among evidence-based obesity treatments Always get a serum B12 blood test before booking clinic injections if your levels are normal, B12 shots will not change your weight MIC shots are not FDA-approved for weight loss and formulas vary significantly between clinics People on long-term metformin, vegans, post-bariatric surgery patients, and adults over 65 are at highest risk of genuine B12 deficiency and benefit most from injections For injection-based weight loss with robust clinical evidence, GLP-1 medications like semaglutide are the current standard of care References Green R, Allen LH, Bjorke-Monsen AL, et al
Taylor AA, Tsuji JS, Garry MR, McArdle ME, Goodfellow WL, Adams WJ, et al
In theory, direct PKA-driven activation of uncoupling proteins may accelerate mitochondrial fat oxidation
Vitamin B12 deficiencies are characterized by: Muscle weakness or fatigue Digestive problems Nervous system disorders Heart damage Most people get enough vitamin B12 just by eating a diet that includes animal products
*Newly Discovered Autoantibodies Block CD320 protein from carrying B12 to the Brain* In April 2024, a paper was published showing that low B12 in the brain can be tied to autoimmunity
