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However, metformin extended-release preparations are absorbed into the bloodstream through intestinal transit proteins in about 50% of the amount of the regular preparations, but they have similar glucose-lowering effects compared to the regular preparations (Buse et al., 2016)

If your GLP-1 therapy feels ineffective, the issue usually stems from one of several identifiable factors: genetic variations affecting how your body processes the medication, insufficient dosing for your metabolism, medication tolerance, lifestyle barriers, or an underlying condition interfering with results