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Advise patients to discontinue XIGDUO XR immediately and to promptly notify their healthcare provider if unexplained hyperventilation, myalgia, malaise, unusual somnolence, dizziness, slow or irregular heartbeat, sensation of feeling cold (especially in the extremities), or other nonspecific symptoms occur

This gap in evidence means healthcare providers cannot definitively say the drugs are safe or unsafe during breastfeedingonly that the data is insufficient to recommend routine use

The population comprised overweight or obese individuals enrolled in RCTs

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(2024, September)