Table 1 summarizes the main features of each disease, how these drugs protect the brain, and the improvements seen in preclinical models
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In the context of glycolysis, insulin increases the activity of key enzymes, such as 6-phosphofructokinase and pyruvate kinase, which facilitate the conversion of glucose to pyruvate and lactate
All eight behavioral assessments (see below) were split between these two visits, lasting an average of 2 h each
Collectively, these observations indicate that anaplerotic glutamine metabolism is highly responsible for energy generation in cancer cells