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Since kidney function is reduced during AKI, activation of the urea cycle and subsequent urea generation together lead to a substantial rise in BUN 14,35

This one has slightly better evidence

Effects of dexmedetomidine pretreatment, posttreatment, and whole-course pumping on myocardial damage during cardiac valve replacement

Reducing the risk of metabolic diseases: Inhibiting NNMT may counteract the adverse metabolic changes associated with obesity, such as fatty liver disease

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