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The smaller surface area also makes site rotation more challenging, increasing the risk of skin irritation and lipohypertrophy

These include genetic predisposition (the strongest predictor), hormonal factors (estrogen, insulin, thyroid hormones), age-related changes in skin elasticity and thickness, lifestyle factors such as physical inactivity and poor nutrition, and overall body composition

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Some research suggests tirzepatide users may experience fewer severe GI side effects than expected given its dual mechanism, but responses are highly individual

Petersen, K