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415,418 Besides, adaptive upregulation of multiple RTKs including Erb-B2 receptor tyrosine kinase 3 (ERBB3), PDGFR, EGFR, and FGFR contributes to cell survival and protects tumor cells from apoptosis induced by BRAF inhibition

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115 116 Mechanistically, alcohol-induced CYP2E1 overexpression enhances HBV replication by upregulating hepatocyte nuclear factor-4, the key transcription factor for the HBV core promoter, 117 and increases HCV-related mitochondrial ROS, reducing antioxidant capacity and depleting mitochondrial glutathione, which heightens oxidative damage and cell death