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Subsequently, methylene blue generated in older erythrocytes could diffuse back to the younger erythrocytes and so on forming a persistent metabolic cycle between younger and older erythrocytes

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The impact might be short-term

Comparing FN to COL I revealed downregulation of genes associated with melanocytic differentiation on FN, such as Apoe , next to the previously mentioned MITF target genes (e.g., Dct , Pmel , Tyr , Trpm1 , Gpr143 , and Irf4 ) and melanin biosynthesis-related genes (e.g., Oca2 , Adcy2) (Fig

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