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The role of tryptophan metabolism in the occurrence and progression of acute and chronic kidney diseases

Surprisingly, ASG-10 were not very sensitive to rotenone even at 5 M

As expected, the strictly conserved Asn419 hTrxR1 appears to be the most important residue for aligning the flexible C-terminal arm during catalysis, because a simultaneous mutation of all three guiding bar residues (Trp407 hTrxR1 , Asn418 hTrxR1 , and Asn419 hTrxR1 ) led only to a minor increase in hTrx1- and DTNB-reduction activity of hTrxR1 compared to the mutation of Asn419 hTrxR1 alone (Table 2)

M.FlorindoH.FerreiraD.SarmentoB

Additionally, xenograft tumor data showed that Gln significantly promoted tumor growth in vivo (Fig