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Moreover, mediators can interact with the nerve terminals or ion channels in the airways to inhibit or promote depolarisation, alter the response to activating stimuli, or lead to changes in gene expression modifying the function of the sensory fibre itself (Taylor-Clark & Undem, 2006)

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Naturally we have to look at the historical context of this so here are two of Ace's later recollections: "We were on our first tour of Canada and I got some fireworks and said to myself, 'I wonder what would happen if I put a smoke bomb inside my Les Paul'