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Similar content being viewed by others 1 Introduction Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by pathological angiogenesis and increased angiogenic factor production, which leads to increased percolation of endothelial cells, that promotes synovitis followed by bone and cartilaginous damages, resulting in, progressive changes and destruction in joints [1]

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Fourth, confounding factors such as mental health may not have been adjusted for

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