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This probably reflects substitution of trazodone for BZDs as sedative/hypnotics, especially after regulators and guidelines discouraged prescription of BZDs starting about 2012

Epub 2016 Sep 21

However, this doesnt preclude the use of proxy measures of outcomes, such as changes in risk behaviours, such as smoking

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Recheck serum estradiol 6 to 8 weeks after verified cessation and adjust patch dose downward if estradiol levels rise above the mid-follicular target range (approximately 40 to 100 pg/mL for symptomatic HRT)