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Increased levels of ROS contribute to inactivation of antiproteases (such as a1-antitrypsin) and activation of metalloproteases (MMPs), resulting in protease/antiprotease imbalance in the lungs, which directly contributes to the degradation of the lung matrix [94]
Finally, CBD can significantly inhibit SARS-Cov-2 replication in mouse models of infection, thereby reducing the viral load in the lungs and reducing signs of clinical disease [178]
Even so, the mechanistic picture points to risk, not benefit, especially with regular exposure
Another study comparing association between tobacco smoking and chewing with risk of PID in two populations with different exposures showed that SLT users were at a five times higher risk of SIL in comparison to non-chewers irrespective of age (Simen-Kapeu et al
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