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For more on the overall treatment experience, see our overview of GLP-1 side effects in 2026

Second, with any short-term agent, durability is the weak point short-term weight loss is common, but the majority of patients regain weight over the following years unless the underlying behavior and physiology are addressed

doi:10.21037/tau.2020.04.05

Diffuse pigmentation includes physiologic pigmentation, pigmented hairy tongue, and medication-induced pigmentation

In a recent regulatory shift, the FDA has ended the allowance for compounding pharmacies to produce copycat versions of popular GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)