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Nature 2021;600:47883
Importantly, the smokers were not selected because they wanted to quit and they were not instructed to use the e-cigarettes, only mildly encouraged (You are not required to use the e-cigarettes, but you might want to give them a try.) After six months, outcomes were compared to a similar group of smokers who were not given e-cigarettes (although some of them vaped spontaneously)
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The largest reductions were observed among African Americans (3.48 pp, 95% CI: 9.25 to 2.29 pp) and American Indian/Alaska Natives (AIANs) and multiracial respondents (4.53 pp, 95% CI: 9.98 to 0.92 pp), although the CIs for these groups included the null
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