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MD simulations also identified a natural compound schisandrin B (Sch B) that specifically bound to the ligand-binding domain of PXR, induced conformational changes and disrupted the PARP1PXR interaction interface, thus suppressed the ribosylation

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FOXO4 is a member of the broader FOXO protein family, which has preserved both structural and functional characteristics across various animal species and has long been associated with pathways influencing aging

Nat Chem Biol 16:302309 Kazan HH, Urfali-Mamatoglu C, Gunduz U (2017) Iron metabolism and drug resistance in cancer